BAIT
RFWD2
COP1, RNF200, RP11-318C24.3
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
OGT
HRNT1, O-GLCNAC
O-linked N-acetylglucosamine (GlcNAc) transferase
GO Process (24)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [IDA]
- cellular response to retinoic acid [IMP]
- chromatin organization [TAS]
- circadian regulation of gene expression [ISS]
- histone H3-K4 trimethylation [IMP]
- histone H4-K16 acetylation [IDA]
- histone H4-K5 acetylation [IDA]
- histone H4-K8 acetylation [IDA]
- negative regulation of protein ubiquitination [ISS]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of catalytic activity [IDA]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of histone H3-K27 methylation [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- protein O-linked glycosylation [IDA, IMP]
- regulation of Rac protein signal transduction [IDA]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [ISS]
- regulation of glycolytic process [IDA]
- regulation of insulin receptor signaling pathway [IDA]
- response to insulin [IDA]
- response to nutrient [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates.
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ?20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates. Among them, CUL4 associates with DDB1 to form the CUL4-DDB1 ubiquitin ligase complex, which is involved in protein ... [more]
Mol Cell Proteomics Sep. 07, 2023; ();100644 [Pubmed: 37689310]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID