BAIT
TLE3
ESG, ESG3, GRG3, HsT18976
transducin-like enhancer of split 3
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [TAS]
Homo sapiens
PREY
SPTBN4
QV, SPNB4, SPTBN3
spectrin, beta, non-erythrocytic 4
GO Process (14)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- adult walking behavior [ISS]
- axon guidance [TAS]
- axonogenesis [ISS]
- cardiac conduction [ISS]
- central nervous system projection neuron axonogenesis [ISS]
- clustering of voltage-gated sodium channels [ISS]
- cytoskeletal anchoring at plasma membrane [TAS]
- establishment of protein localization to plasma membrane [ISS]
- negative regulation of heart rate [ISS]
- regulation of peptidyl-serine phosphorylation [ISS]
- regulation of sodium ion transport [ISS]
- sensory perception of sound [ISS]
- transmission of nerve impulse [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- PML body [IDA, ISS]
- adherens junction [ISS]
- axon hillock [ISS]
- axon initial segment [ISS]
- cell body fiber [ISS]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- neuronal cell body [ISS]
- node of Ranvier [ISS]
- nuclear matrix [IDA, ISS]
- plasma membrane [ISS]
- spectrin [IDA, ISS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates.
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ?20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates. Among them, CUL4 associates with DDB1 to form the CUL4-DDB1 ubiquitin ligase complex, which is involved in protein ... [more]
Mol Cell Proteomics Sep. 07, 2023; ();100644 [Pubmed: 37689310]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID