BAIT
METTL14
methyltransferase like 14
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACACA
ACAC, ACACAD, ACC, ACC1, ACCA
acetyl-CoA carboxylase alpha
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [ISS]
- biotin metabolic process [TAS]
- carnitine shuttle [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- fatty acid biosynthetic process [ISS]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- positive regulation of cellular metabolic process [TAS]
- protein homotetramerization [ISS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.
N6 -Methyladenosine (m6 A) is an important RNA modification catalyzed by methyltransferase-like 3 (METTL3) and METTL14. m6 A homeostasis mediated by the methyltransferase (MTase) complex plays key roles in various biological processes. However, the mechanism underlying METTL14 protein stability and its role in m6 A homeostasis remain elusive. Here, we show that METTL14 stability is regulated by the competitive interaction ... [more]
EMBO Rep Mar. 06, 2023; 24(3);e55762 [Pubmed: 36597993]
Throughput
- High Throughput
Curated By
- BioGRID