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BAIT

METTL14

methyltransferase like 14

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

mRNA destabilization [ISS]

mRNA methylation [IMP]

stem cell maintenance [ISS]

Gene Ontology Molecular Function

mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [IDA]

Gene Ontology Cellular Component

MIS complex [IDA]

nucleoplasm [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

VCP

ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97

valosin containing protein

Autophagy Project

GO Process (18)

GO Function (8)

GO Component (13)

Gene Ontology Biological Process

DNA repair [NAS]

ER-associated ubiquitin-dependent protein catabolic process [IDA, IMP, TAS]

activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]

cellular response to DNA damage stimulus [IDA]

double-strand break repair [IDA]

endoplasmic reticulum unfolded protein response [TAS]

establishment of protein localization [TAS]

positive regulation of Lys63-specific deubiquitinase activity [IDA]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]

positive regulation of protein K63-linked deubiquitination [IDA]

positive regulation of protein catabolic process [IDA]

positive regulation of protein complex assembly [IDA]

proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]

protein N-linked glycosylation via asparagine [IMP]

protein ubiquitination [IDA, NAS]

regulation of apoptotic process [TAS]

retrograde protein transport, ER to cytosol [IDA]

translesion synthesis [IMP]

Gene Ontology Molecular Function

ATPase activity [TAS]
deubiquitinase activator activity [IDA]
poly(A) RNA binding [IDA]
polyubiquitin binding [IDA]
protein binding [IPI]
protein domain specific binding [IPI]
protein phosphatase binding [IPI]
ubiquitin-specific protease binding [IPI]

Gene Ontology Cellular Component

Hrd1p ubiquitin ligase complex [IDA]

cytoplasm [IDA]

endoplasmic reticulum [IDA]

endoplasmic reticulum membrane [IDA]

extracellular vesicular exosome [IDA]

intracellular membrane-bounded organelle [ISS]

lipid particle [IDA]

nucleoplasm [IDA]

nucleus [IDA, TAS]

perinuclear region of cytoplasm [IDA]

proteasome complex [IDA]

site of double-strand break [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

Zeng ZC, Pan Q, Sun YM, Huang HJ, Chen XT, Chen TQ, He B, Ye H, Zhu SX, Pu KJ, Fang K, Huang W, Chen YQ, Wang WT

N6 -Methyladenosine (m6 A) is an important RNA modification catalyzed by methyltransferase-like 3 (METTL3) and METTL14. m6 A homeostasis mediated by the methyltransferase (MTase) complex plays key roles in various biological processes. However, the mechanism underlying METTL14 protein stability and its role in m6 A homeostasis remain elusive. Here, we show that METTL14 stability is regulated by the competitive interaction ... [more]

EMBO Rep Mar. 06, 2023; 24(3);e55762 [Pubmed: 36597993]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
METTL14 VCP	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Yue Y (2018)	High	-	BioGRID	2566214

Curated By

BioGRID