BAIT

METTL14

methyltransferase like 14
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CELSR3

CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1
cadherin, EGF LAG seven-pass G-type receptor 3
GO Process (1)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

Zeng ZC, Pan Q, Sun YM, Huang HJ, Chen XT, Chen TQ, He B, Ye H, Zhu SX, Pu KJ, Fang K, Huang W, Chen YQ, Wang WT

N6 -Methyladenosine (m6 A) is an important RNA modification catalyzed by methyltransferase-like 3 (METTL3) and METTL14. m6 A homeostasis mediated by the methyltransferase (MTase) complex plays key roles in various biological processes. However, the mechanism underlying METTL14 protein stability and its role in m6 A homeostasis remain elusive. Here, we show that METTL14 stability is regulated by the competitive interaction ... [more]

EMBO Rep Mar. 06, 2023; 24(3);e55762 [Pubmed: 36597993]

Throughput

  • High Throughput

Curated By

  • BioGRID