TXN
Gene Ontology Biological Process
- activation of protein kinase B activity [IC]
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- negative regulation of hydrogen peroxide-induced cell death [IGI]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- oxidation-reduction process [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of protein kinase B signaling [IC]
- regulation of protein import into nucleus, translocation [IDA]
- response to radiation [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRDX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines.
Ataxia-Telangiectasia (A-T), a pleiotropic chromosomal breakage syndrome, is caused by the loss of the kinase Ataxia-telangiectasia mutated (ATM). ATM is not only involved in the response to DNA damage, but also in sensing and counteracting oxidative stress. Since a disturbed redox balance has been implicated in the pathophysiology of A-T lung disease, we aimed to further explore the interplay between ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TXN PRDX1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 818145 | |
| PRDX1 TXN | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.0742 | BioGRID | 1273831 |
Curated By
- BioGRID