BAIT

COF1

cofilin, L000000377, YLL050C
Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
GO Process (5)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

POR1

OMP2, porin POR1, VDAC, YVDAC1, L000001302, YNL055C
Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; couples the glutathione pools of the intermembrane space (IMS) and the cytosol; interacts with Om45 and Om14 in the outer membrane; phosphorylated; protein abundance increases in response to DNA replication stress
Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis.

Davis J, Meyer T, Smolnig M, Smethurst DGJ, Neuhaus L, Heyden J, Broeskamp F, Edrich ESM, Knittelfelder O, Kolb D, Haar TV, Gourlay CW, Rockenfeller P

The dynamic nature of the actin cytoskeleton is required to coordinate many cellular processes, and a loss of its plasticity has been linked to accelerated cell aging and attenuation of adaptive response mechanisms. Cofilin is an actin-binding protein that controls actin dynamics and has been linked to mitochondrial signaling pathways that control drug resistance and cell death. Here we show ... [more]

iScience Sep. 15, 2023; 26(9);107539 [Pubmed: 37636069]

Throughput

  • Low Throughput

Ontology Terms

  • chemical compound accumulation (APO:0000095)
  • actin cytoskeleton morphology (APO:0000120)
  • cell size (APO:0000052)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
COF1 POR1
Synthetic Rescue
Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Low-BioGRID
3572221

Curated By

  • BioGRID