RNF5
Gene Ontology Biological Process
Gene Ontology Molecular Function
EPHA4
Gene Ontology Biological Process
- corticospinal tract morphogenesis [ISS]
- fasciculation of motor neuron axon [ISS]
- fasciculation of sensory neuron axon [ISS]
- motor neuron axon guidance [ISS]
- negative regulation of axon regeneration [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of Rho guanyl-nucleotide exchange factor activity [IDA]
- protein autophosphorylation [IDA]
- regulation of Rac GTPase activity [ISS]
- regulation of Rap GTPase activity [ISS]
- regulation of astrocyte differentiation [ISS]
- regulation of axonogenesis [ISS]
- regulation of dendritic spine morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition.
Primary effusion lymphoma (PEL), a rare aggressive B-cell lymphoma in immunosuppressed patients, is etiologically associated with oncogenic ?-herpesvirus infection. Chemotherapy is commonly used to treat PEL but usually results in poor prognosis and survival; thus, novel therapies and drug development are urgently needed for PEL treatment. Here, we demonstrated that inhibition of Ring finger protein 5 (RNF5), an ER-localized E3 ... [more]
Throughput
- Low Throughput
Additional Notes
- E2 not specified
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNF5 EPHA4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| EPHA4 RNF5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID