SEN1
Gene Ontology Biological Process
- DNA-dependent DNA replication maintenance of fidelity [IMP]
- DNA-templated transcription, termination [IMP]
- mRNA 3'-end processing [IMP]
- mRNA polyadenylation [IMP]
- rRNA processing [IMP]
- regulation of transcription from RNA polymerase II promoter in response to DNA damage [IMP]
- snRNA processing [IMP]
- snoRNA 3'-end processing [IMP]
- tRNA processing [IMP]
- termination of RNA polymerase II transcription [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RRM3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
Replication forks terminate at TERs and telomeres. Forks that converge or encounter transcription generate topological stress. Combining genetics, genomics, and transmission electron microscopy, we find that Rrm3hPif1 and Sen1hSenataxin helicases assist termination at TERs; Sen1 specifically acts at telomeres. rrm3 and sen1 genetically interact and fail to terminate replication, exhibiting fragility at termination zones (TERs) and telomeres. sen1rrm3 accumulates RNA-DNA ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RRM3 SEN1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2375 | BioGRID | 2047269 | |
SEN1 RRM3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2395 | BioGRID | 2003632 |
Curated By
- BioGRID