BAIT
PARK2
Park, Prkn
parkin RBR E3 ubiquitin protein ligase
GO Process (63)
GO Function (22)
GO Component (22)
Gene Ontology Biological Process
- adult locomotory behavior [ISO, ISS]
- aggresome assembly [ISO, ISS]
- cellular protein catabolic process [ISO]
- cellular protein modification process [TAS]
- cellular response to toxic substance [ISO, ISS]
- dopamine metabolic process [ISO]
- dopamine uptake involved in synaptic transmission [ISO]
- learning [ISO]
- locomotory behavior [ISO]
- mitochondrial fission [ISS]
- mitochondrion degradation [ISO, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of cell death [ISO]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of glucokinase activity [ISO, ISS]
- negative regulation of insulin secretion [ISO, ISS]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [ISO, ISS]
- negative regulation of neuron death [IGI, ISO]
- negative regulation of oxidative stress-induced neuron death [IGI]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of reactive oxygen species metabolic process [ISO, ISS]
- negative regulation of release of cytochrome c from mitochondria [ISO, ISS]
- neuron cellular homeostasis [ISS]
- neuron maturation [IEP]
- norepinephrine metabolic process [ISO]
- positive regulation of DNA binding [ISO, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [ISO, ISS]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein linear polyubiquitination [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of tumor necrosis factor-mediated signaling pathway [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO, ISS]
- protein K48-linked ubiquitination [ISO, ISS]
- protein K63-linked ubiquitination [ISO, ISS]
- protein autoubiquitination [ISO, ISS]
- protein localization to mitochondrion [ISS]
- protein metabolic process [ISO]
- protein monoubiquitination [ISO, ISS]
- protein polyubiquitination [ISO, ISS]
- protein ubiquitination [ISO, ISS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- regulation of autophagy [ISO, ISS]
- regulation of cellular response to oxidative stress [ISS]
- regulation of mitochondrion organization [ISO, ISS]
- regulation of neurotransmitter secretion [ISO]
- regulation of reactive oxygen species metabolic process [ISO]
- regulation of synaptic transmission [ISO]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to endoplasmic reticulum stress [ISO]
- response to oxidative stress [ISS]
- response to unfolded protein [IDA]
- startle response [ISO]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [ISO]
- ubiquitin-dependent protein catabolic process [TAS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [ISO, ISS]
- G-protein coupled receptor binding [ISO, ISS]
- Hsp70 protein binding [ISO, ISS]
- PDZ domain binding [ISO, ISS]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO, ISS]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO, ISS]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO, ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
- tubulin binding [ISO]
- ubiquitin binding [ISO, ISS]
- ubiquitin conjugating enzyme binding [ISO, ISS]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS, TAS]
- ubiquitin-specific protease binding [ISO]
- F-box domain binding [ISO, ISS]
- G-protein coupled receptor binding [ISO, ISS]
- Hsp70 protein binding [ISO, ISS]
- PDZ domain binding [ISO, ISS]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO, ISS]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO, ISS]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO, ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
- tubulin binding [ISO]
- ubiquitin binding [ISO, ISS]
- ubiquitin conjugating enzyme binding [ISO, ISS]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS, TAS]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi membrane [IDA]
- LUBAC complex [ISO, ISS]
- Parkin-FBXW7-Cul1 ubiquitin ligase complex [ISO, ISS]
- SCF ubiquitin ligase complex [ISO]
- aggresome [ISO, ISS]
- cytoplasm [IDA, ISO, ISS]
- cytoplasmic vesicle [IDA]
- cytosol [ISO, ISS]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [IDA]
- intracellular [IDA]
- membrane raft [IDA]
- mitochondrion [ISO, ISS]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- synapse [IDA]
- synaptic vesicle [IDA]
- ubiquitin ligase complex [ISO, ISS]
Rattus norvegicus
PREY
UBE2D3
E2(17)KB3, UBC4/5, UBCH5C
ubiquitin-conjugating enzyme E2D 3
GO Process (23)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular protein modification process [TAS]
- cellular response to hypoxia [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of type I interferon production [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K11-linked ubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.
RING-between RING (RBR)-type ubiquitin (Ub) ligases (E3s) such as Parkin receive Ub from Ub-conjugating enzymes (E2s) in response to ligase activation. However, the specific E2s that transfer Ub to each RBR-type ligase are largely unknown because of insufficient methods for monitoring their interaction. To address this problem, we have developed a method that detects intracellular interactions between E2s and activated ... [more]
J Biol Chem Feb. 01, 2023; 299(2);102822 [Pubmed: 36563856]
Throughput
- Low Throughput
Curated By
- BioGRID