BAIT
ACE2
ACEH, UNQ868/PRO1885
angiotensin I converting enzyme 2
GO Process (15)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- angiotensin catabolic process in blood [IC]
- angiotensin maturation [TAS]
- angiotensin-mediated drinking behavior [IMP]
- cellular protein metabolic process [TAS]
- positive regulation of reactive oxygen species metabolic process [IC]
- receptor biosynthetic process [IMP]
- receptor-mediated virion attachment to host cell [IDA]
- regulation of cell proliferation [TAS]
- regulation of cytokine production [IC]
- regulation of inflammatory response [IC]
- regulation of systemic arterial blood pressure by renin-angiotensin [IC, IMP]
- regulation of vasoconstriction [IC]
- regulation of vasodilation [IC]
- response to virus [IDA, IMP]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CADM1
BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1
cell adhesion molecule 1
GO Process (12)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- T cell mediated cytotoxicity [IDA]
- activated T cell proliferation [IDA]
- adherens junction organization [TAS]
- cell junction assembly [TAS]
- cell recognition [IDA, ISS]
- cell-cell junction organization [TAS]
- detection of stimulus [IDA, ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISS]
- positive regulation of cytokine secretion [IDA]
- positive regulation of natural killer cell mediated cytotoxicity [IDA, ISS]
- susceptibility to natural killer cell mediated cytotoxicity [IDA, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.
Identifying virus-host interactions on the cell surface can improve our understanding of viral entry and pathogenesis. SARS-CoV-2, the causative agent of the COVID-19 disease, uses ACE2 as a receptor to enter cells. Yet the full repertoire of cell surface proteins that contribute to viral entry is unknown. We developed a photocatalyst-based viral-host protein microenvironment mapping platform (ViraMap) to probe the ... [more]
Cell Chem Biol Jul. 17, 2023; (); [Pubmed: 37499664]
Throughput
- High Throughput
Additional Notes
- Enriched hits were identified with significant enrichment (log2FC greater than or equal to 1.5 and -log10p value of greater than or equal to 2 over control) and a SAINT BFDR of less than or equal to 0.01.
- Photocatalyst-based microenvironment mapping platform.
Curated By
- BioGRID