BAIT

SWR1

chromatin-remodeling protein SWR1, S000007447, YDR334W
Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction
GO Process (2)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ADA2

SWI8, chromatin-binding transcription regulator ADA2, L000000029, YDR448W
Transcription coactivator; component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest.

Caydasi AK, Khmelinskii A, Darieva Z, Kurtulmus B, Knop M, Pereira G

Faithful chromosome segregation in budding yeast requires correct positioning of the mitotic spindle along the mother to daughter cell polarity axis. When the anaphase spindle is not correctly positioned, a surveillance mechanism, named as the spindle position checkpoint (SPOC), prevents the progression out of mitosis until correct spindle positioning is achieved. How SPOC works on a molecular level is not ... [more]

Mol Biol Cell Feb. 01, 2023; 34(2);ar11 [Pubmed: 36542480]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: position of spindle pole body (APO:0000214)

Additional Notes

  • 69 gene deletions that caused growth defects specifically in GAL1-KIN4/swr1 mutant cells but not in swr1 mutant cells on galactose-containing plates thus suppressing the SPOC bypass seen in an swr1 mutant

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ADA2 SWR1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-3.6642BioGRID
541112
ADA2 SWR1
Synthetic Rescue
Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

High-BioGRID
505590

Curated By

  • BioGRID