BAIT
OTUD7A
AJ430384, Otud7
OTU domain containing 7A
GO Process (2)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
NOS1
2310005C01Rik, NO, NOS-I, Nos-1, bNOS, nNOS
nitric oxide synthase 1, neuronal
GO Process (40)
GO Function (15)
GO Component (20)
Gene Ontology Biological Process
- arginine catabolic process [ISO]
- behavioral response to cocaine [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to growth factor stimulus [IMP]
- cellular response to mechanical stimulus [ISO]
- exogenous drug catabolic process [IMP]
- multicellular organismal response to stress [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of blood pressure [IBA, ISO]
- negative regulation of calcium ion transport [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of hydrolase activity [IMP]
- negative regulation of insulin secretion [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of potassium ion transport [IMP]
- negative regulation of serotonin uptake [IDA]
- negative regulation of vasoconstriction [ISO]
- nitric oxide biosynthetic process [IDA, ISO]
- nitric oxide mediated signal transduction [IBA, ISO]
- oxidation-reduction process [IBA]
- peptidyl-cysteine S-nitrosylation [IDA, ISO]
- positive regulation of adrenergic receptor signaling pathway involved in heart process [IMP]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [IMP]
- positive regulation of long-term synaptic potentiation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of sodium ion transmembrane transport [ISO]
- positive regulation of the force of heart contraction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of vasodilation [IBA, ISO]
- regulation of heart contraction [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of sodium ion transport [IMP]
- response to estrogen [ISO]
- response to heat [ISO]
- response to peptide hormone [ISO]
- striated muscle contraction [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
Gene Ontology Cellular Component
- azurophil granule [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IBA, ISO]
- dendrite [ISO]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [ISO]
- mitochondrion [ISO]
- nuclear membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- photoreceptor inner segment [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [ISO]
- synapse [IDA, ISO]
- vesicle membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.
Copy number variations (CNVs) are associated with psychiatric and neurodevelopmental disorders (NDDs), and most, including the recurrent 15q13.3 microdeletion disorder, have unknown disease mechanisms. We used a heterozygous 15q13.3 microdeletion mouse model and patient iPSC-derived neurons to reveal developmental defects in neuronal maturation and network activity. To identify the underlying molecular dysfunction, we developed a neuron-specific proximity-labeling proteomics (BioID2) pipeline, ... [more]
Mol Psychiatry Apr. 01, 2023; 28(4);1747-1769 [Pubmed: 36604605]
Throughput
- Low Throughput
Curated By
- BioGRID