OTUD7A
Gene Ontology Biological Process
Gene Ontology Molecular Function
ANK3
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISO]
- axon guidance [IMP]
- axonogenesis [IMP]
- establishment of protein localization [ISO]
- maintenance of protein location in plasma membrane [ISO]
- membrane assembly [ISO]
- mitotic cytokinesis [ISO]
- neuronal action potential [IMP]
- plasma membrane organization [ISO]
- positive regulation of action potential [TAS]
- positive regulation of cation channel activity [ISO]
- positive regulation of cell communication by electrical coupling [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of homotypic cell-cell adhesion [ISO]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [ISO]
- positive regulation of membrane potential [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of sodium ion transmembrane transporter activity [ISO]
- positive regulation of sodium ion transport [ISO]
- protein localization to plasma membrane [IDA, IMP, ISO]
- protein targeting to plasma membrane [IMP, ISO]
- regulation of potassium ion transport [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- Z disc [ISO]
- axon [IDA]
- axon initial segment [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell [IMP]
- cell surface [ISO]
- dendrite [ISO]
- intercalated disc [IDA, ISO]
- intracellular [IMP]
- lateral plasma membrane [ISO]
- membrane [IDA]
- neuromuscular junction [ISO]
- neuron projection [ISO]
- node of Ranvier [IDA, ISO]
- paranode region of axon [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- sarcolemma [ISO]
- sarcoplasmic reticulum [ISO]
- spectrin-associated cytoskeleton [ISO]
- synapse [IDA]
- tight junction [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.
Copy number variations (CNVs) are associated with psychiatric and neurodevelopmental disorders (NDDs), and most, including the recurrent 15q13.3 microdeletion disorder, have unknown disease mechanisms. We used a heterozygous 15q13.3 microdeletion mouse model and patient iPSC-derived neurons to reveal developmental defects in neuronal maturation and network activity. To identify the underlying molecular dysfunction, we developed a neuron-specific proximity-labeling proteomics (BioID2) pipeline, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OTUD7A ANK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID