BAIT

TRIM41

RINCK

tripartite motif containing 41

GO Process (0)

GO Function (1)

GO Component (1)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

nucleolus [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

UBE2D1

E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A

ubiquitin-conjugating enzyme E2D 1

Cell Cycle - Senescence Project

GO Process (24)

GO Function (3)

GO Component (5)

Gene Ontology Biological Process

BMP signaling pathway [TAS]

MyD88-independent toll-like receptor signaling pathway [TAS]

TRIF-dependent toll-like receptor signaling pathway [TAS]

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]

cellular response to hypoxia [TAS]

gene expression [TAS]

innate immune response [TAS]

mitotic cell cycle [TAS]

mitotic spindle assembly checkpoint [TAS]

negative regulation of transcription from RNA polymerase II promoter [TAS]

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

positive regulation of protein ubiquitination [IDA]

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

protein K48-linked ubiquitination [IDA]

protein polyubiquitination [IDA]

regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

toll-like receptor 3 signaling pathway [TAS]

toll-like receptor 4 signaling pathway [TAS]

toll-like receptor signaling pathway [TAS]

transcription initiation from RNA polymerase II promoter [TAS]

transcription, DNA-templated [TAS]

transforming growth factor beta receptor signaling pathway [TAS]

ubiquitin-dependent protein catabolic process [IDA]

Gene Ontology Molecular Function

protein binding [IPI]
ubiquitin conjugating enzyme activity [IDA]
ubiquitin-protein transferase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleoplasm [TAS]

protein complex [IDA]

ubiquitin ligase complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

circRNA_0067717 promotes paclitaxel resistance in nasopharyngeal carcinoma by acting as a scaffold for TRIM41 and p53.

Cheng Y, Zhu Y, Xiao M, Zhang Y, Wang Z, Chen H, Cao K

Circular RNAs (circRNAs) play important roles in tumour progression. This study aimed to explore the mechanism of hsa_circ_0067717 (termed circRNA_0067717) promoting paclitaxel resistance in nasopharyngeal carcinoma (NPC).We assayed CNE-1 and HNE-2 parental cell lines and the corresponding paclitaxel-resistant NPC cell lines using circRNA microarrays. RNA pull-down assay, RNA immunoprecipitation, and RNA fluorescence in situ hybridization were used to identify the ... [more]

Cell Oncol (Dordr) Jun. 01, 2023; 46(3);677-695 [Pubmed: 36705889]

Throughput

Low Throughput

Additional Notes

The reaction contained UBA1 [E1], UBE2D1 [E2], and TRIM41 [E3]

Curated By

BioGRID