NT5E
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
USP22
Gene Ontology Biological Process
- histone H4 acetylation [ISO]
- histone deubiquitination [IBA, ISO]
- histone ubiquitination [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, ISO]
- proteolysis [ISO]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of transcription, DNA-templated [IBA]
- ubiquitin-dependent protein catabolic process [IC]
Gene Ontology Molecular Function- H4 histone acetyltransferase activity [ISO]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- transcription coactivator activity [ISO]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, ISO]
- H4 histone acetyltransferase activity [ISO]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- transcription coactivator activity [ISO]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The ubiquitin-specific peptidase 22 is a deubiquitinase of CD73 in breast cancer cells.
Cancer cells evade the immune system by expressing inhibitory immune checkpoint receptors such as ecto-5'-nucleotidase (NT5E), also known as CD73, which consequently suppress tumor neoantigen-specific immune response. Blockade of CD73 in mouse models of breast cancer showed a reduction in tumor growth and metastasis. CD73 expression is elevated in a variety of human tumors including breast cancer. While the regulation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID