BAIT
PRNP
ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, RP5-1068H6.2
prion protein
GO Process (12)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- axon guidance [TAS]
- cellular copper ion homeostasis [NAS]
- metabolic process [TAS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of calcineurin-NFAT signaling cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-2 production [ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- response to oxidative stress [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCARB1
CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1
scavenger receptor class B, member 1
GO Process (24)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- adhesion of symbiont to host [IMP]
- cholesterol efflux [ISS]
- cholesterol homeostasis [ISS]
- cholesterol import [ISS]
- detection of lipopolysaccharide [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [ISS]
- lipopolysaccharide transport [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle clearance [ISS]
- phospholipid transport [ISS]
- positive regulation of cholesterol storage [IDA]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of triglyceride biosynthetic process [ISS]
- receptor-mediated endocytosis [IDA]
- recognition of apoptotic cell [IDA]
- regulation of phagocytosis [IC]
- regulation of phosphatidylcholine catabolic process [ISS]
- reverse cholesterol transport [IEP]
- small molecule metabolic process [TAS]
- triglyceride homeostasis [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function- 1-phosphatidylinositol binding [TAS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein binding [IPI]
- high-density lipoprotein particle receptor activity [IDA]
- lipopolysaccharide binding [IDA]
- lipopolysaccharide receptor activity [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [ISS]
- protein binding [IPI]
- transporter activity [TAS]
- 1-phosphatidylinositol binding [TAS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein binding [IPI]
- high-density lipoprotein particle receptor activity [IDA]
- lipopolysaccharide binding [IDA]
- lipopolysaccharide receptor activity [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [ISS]
- protein binding [IPI]
- transporter activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.
Aberrant activation of receptor tyrosine kinase (RTK) is usually a result of mutation and plays important roles in tumorigenesis. How RTK without mutation affects tumorigenesis remains incompletely understood. Here we show that in human melanomas pro-prion (pro-PrP) is an adaptor protein for an E3 ligase c-Cbl, enabling it to polyubiquitinate activated insulin-like growth factor-1 receptor (IGF-1R), leading to enhanced melanoma ... [more]
Cell Rep Dec. 20, 2022; 41(12);111834 [Pubmed: 36543142]
Throughput
- Low Throughput
Curated By
- BioGRID