RAB8A
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi vesicle fusion to target membrane [IBA, ISO]
- Rab protein signal transduction [IBA]
- axonogenesis [ISO]
- cellular response to insulin stimulus [IBA, ISO]
- cilium assembly [ISO]
- intracellular protein transport [IBA]
- protein localization to plasma membrane [IBA, ISO]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [ISO]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- centrosome [ISO]
- ciliary basal body [IDA]
- cilium [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- dendrite [ISO]
- extracellular vesicular exosome [ISO]
- neuronal cell body [ISO]
- nonmotile primary cilium [IDA, ISO]
- nucleolus [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- phagocytic vesicle [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- primary cilium [ISO]
- recycling endosome [IDA]
- recycling endosome membrane [ISO]
- secretory granule membrane [IBA]
- synaptic vesicle [IBA]
- trans-Golgi network transport vesicle [IDA]
CD274
Gene Ontology Biological Process
- T cell costimulation [ISO]
- cell surface receptor signaling pathway [ISO]
- immune response [ISO]
- negative regulation of T cell proliferation [IDA]
- negative regulation of activated T cell proliferation [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of interleukin-10 production [ISO]
- negative regulation of tumor necrosis factor superfamily cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of interleukin-10 secretion [ISO]
- signal transduction [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T cell surface. This interaction delivers coinhibitory signals to T cells, thereby suppressing their function and allowing evasion of antitumor immunity. Most companion or ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD274 RAB8A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| CD274 RAB8A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| RAB8A CD274 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 3577568 |
Curated By
- BioGRID