BAIT
CD274
A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
CD274 antigen
GO Process (13)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- T cell costimulation [ISO]
- cell surface receptor signaling pathway [ISO]
- immune response [ISO]
- negative regulation of T cell proliferation [IDA]
- negative regulation of activated T cell proliferation [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of interleukin-10 production [ISO]
- negative regulation of tumor necrosis factor superfamily cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of interleukin-10 secretion [ISO]
- signal transduction [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAB6A
2610028L11Rik, AA419671, Rab6, MNCb-1660
RAB6A, member RAS oncogene family
GO Process (12)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [ISO]
- early endosome to Golgi transport [ISO]
- intra-Golgi vesicle-mediated transport [IBA]
- intracellular protein transport [TAS]
- peptidyl-cysteine methylation [ISO]
- positive regulation of ATPase activity [ISO]
- protein localization to Golgi apparatus [ISO]
- protein targeting to Golgi [ISO]
- retrograde transport, endosome to Golgi [IBA]
- retrograde vesicle-mediated transport, Golgi to ER [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T cell surface. This interaction delivers coinhibitory signals to T cells, thereby suppressing their function and allowing evasion of antitumor immunity. Most companion or ... [more]
J Clin Invest Feb. 01, 2023; 133(3); [Pubmed: 36719382]
Throughput
- Low Throughput
Curated By
- BioGRID