CD274
Gene Ontology Biological Process
- T cell costimulation [ISO]
- cell surface receptor signaling pathway [ISO]
- immune response [ISO]
- negative regulation of T cell proliferation [IDA]
- negative regulation of activated T cell proliferation [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of interleukin-10 production [ISO]
- negative regulation of tumor necrosis factor superfamily cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of interleukin-10 secretion [ISO]
- signal transduction [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB5A
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- Rab protein signal transduction [IBA]
- early endosome to late endosome transport [ISO]
- endocytosis [IDA, ISO]
- endosome organization [ISO]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of endocytosis [IBA]
- regulation of endosome size [ISO]
- regulation of filopodium assembly [IBA, ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic vesicle exocytosis [ISO]
- synaptic vesicle recycling [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [ISO]
- axon terminus [ISO]
- cell [IBA]
- cytoplasm [IDA, ISO]
- cytoplasmic side of early endosome membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- early endosome [IDA, ISO]
- endocytic vesicle [IDA]
- endosome [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- membrane raft [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- phagocytic vesicle [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- recycling endosome [ISO]
- ruffle [IDA]
- somatodendritic compartment [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- zymogen granule membrane [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T cell surface. This interaction delivers coinhibitory signals to T cells, thereby suppressing their function and allowing evasion of antitumor immunity. Most companion or ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD274 RAB5A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID