CD274
Gene Ontology Biological Process
- T cell costimulation [ISO]
- cell surface receptor signaling pathway [ISO]
- immune response [ISO]
- negative regulation of T cell proliferation [IDA]
- negative regulation of activated T cell proliferation [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of interleukin-10 production [ISO]
- negative regulation of tumor necrosis factor superfamily cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of interleukin-10 secretion [ISO]
- signal transduction [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB13
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- Rab protein signal transduction [IBA]
- cellular response to insulin stimulus [ISO]
- cortical actin cytoskeleton organization [IBA, ISO]
- endocytic recycling [IMP, ISO]
- endosomal transport [ISO]
- endothelial cell chemotaxis [IMP]
- establishment of Sertoli cell barrier [ISO]
- establishment of protein localization to plasma membrane [ISO]
- intracellular protein transport [TAS]
- neuron projection development [ISO]
- protein kinase A signaling [ISO]
- protein localization to cell leading edge [IMP]
- protein localization to plasma membrane [ISO]
- tight junction assembly [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [IMP]
- cell-cell junction [IDA]
- cytoplasm [ISO]
- cytoplasmic membrane-bounded vesicle [TAS]
- cytoplasmic vesicle [ISO]
- endocytic vesicle [IDA, ISO]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [TAS]
- insulin-responsive compartment [ISO]
- intracellular [IMP]
- lamellipodium [IDA]
- lateral plasma membrane [ISO]
- neuron projection [ISO]
- plasma membrane [ISO]
- recycling endosome [ISO]
- tight junction [IDA, ISO]
- trans-Golgi network [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T cell surface. This interaction delivers coinhibitory signals to T cells, thereby suppressing their function and allowing evasion of antitumor immunity. Most companion or ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD274 RAB13 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID