TGFBR1
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- angiogenesis [IMP]
- anterior/posterior pattern specification [IGI]
- artery morphogenesis [IMP]
- blastocyst development [IDA]
- cell motility [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- collagen fibril organization [IMP]
- embryo development [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- endothelial cell migration [IMP]
- epithelial to mesenchymal transition [ISO]
- germ cell migration [IMP]
- heart development [IMP]
- in utero embryonic development [IMP]
- kidney development [IGI]
- lens development in camera-type eye [IMP]
- male gonad development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of endothelial cell differentiation [ISO]
- negative regulation of endothelial cell proliferation [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- neuron fate commitment [IMP]
- palate development [IGI, IMP]
- parathyroid gland development [IMP]
- pathway-restricted SMAD protein phosphorylation [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- pharyngeal system development [IMP]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of filopodium assembly [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-embryonic development [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IGI, ISO]
- regulation of gene expression [IMP]
- regulation of protein binding [IMP]
- regulation of protein ubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to cholesterol [IDA, ISO]
- response to estrogen [ISO]
- signal transduction [ISO]
- skeletal system development [IGI]
- skeletal system morphogenesis [IGI]
- thymus development [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, IMP, ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- I-SMAD binding [ISO]
- SMAD binding [IDA, ISO]
- growth factor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [IDA, IGI, ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ATP binding [ISO]
- I-SMAD binding [ISO]
- SMAD binding [IDA, ISO]
- growth factor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [IDA, IGI, ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
BSG
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
N-glycosylation-mediated CD147 accumulation induces cardiac fibrosis in the diabetic heart through ALK5 activation.
Emerging evidence has implicated the important role of fibrosis in diabetic cardiomyopathy (DCM), while the underlying mechanism remains unclear. Considering the distinct and overlapping roles of Cluster of Differentiation 147 (CD147) in the pathogenesis of fibrotic diseases, we aim to investigate the role of CD147 in the fibrosis of DCM and explore its underlying mechanism. AAV9-mediated cardiac-specific CD147 silencing attenuated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BSG TGFBR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID