BAIT
RAB18
AA959686
RAB18, member RAS oncogene family
GO Process (5)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ROBO1
DUTT1, SAX3
roundabout, axon guidance receptor, homolog 1 (Drosophila)
GO Process (13)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- Roundabout signaling pathway [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- axon guidance [TAS]
- axon midline choice point recognition [ISS]
- cell adhesion [TAS]
- cell migration involved in sprouting angiogenesis [IMP]
- chemorepulsion involved in postnatal olfactory bulb interneuron migration [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of chemokine-mediated signaling pathway [IMP]
- negative regulation of mammary gland epithelial cell proliferation [IMP]
- negative regulation of negative chemotaxis [IDA]
- nervous system development [TAS]
- positive regulation of axonogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
Loss of functional RAB18 causes the autosomal recessive condition Warburg Micro syndrome. To better understand this disease, we used proximity biotinylation to generate an inventory of potential RAB18 effectors. A restricted set of 28 RAB18-interactions were dependent on the binary RAB3GAP1-RAB3GAP2 RAB18-guanine nucleotide exchange factor (GEF) complex. 12 of these 28 interactions are supported by prior reports and we have ... [more]
J Biol Chem Sep. 27, 2023; ();105295 [Pubmed: 37774976]
Throughput
- High Throughput
Additional Notes
- BioID
- HeLa cells
- Presence in 2 or more replicate experiments
Curated By
- BioGRID