BAIT
RAB18
AA959686
RAB18, member RAS oncogene family
GO Process (5)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
VAMP7
SYBL1, TI-VAMP, TIVAMP, VAMP-7
vesicle-associated membrane protein 7
GO Process (15)
GO Function (3)
GO Component (19)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [ISS]
- autophagic vacuole fusion [IMP]
- calcium ion-dependent exocytosis [ISS]
- endocytosis [IBA]
- endosome to lysosome transport [IDA]
- eosinophil degranulation [IMP, ISS]
- exocytosis [IBA]
- membrane organization [TAS]
- natural killer cell degranulation [IMP]
- neutrophil degranulation [IMP, ISS]
- phagocytosis, engulfment [ISS]
- positive regulation of histamine secretion by mast cell [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- vesicle fusion [IDA]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- SNARE complex [IDA, ISS]
- azurophil granule membrane [IDA]
- cytoplasm [IDA]
- endoplasmic reticulum membrane [ISS]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [IDA]
- lamellipodium [IDA]
- late endosome membrane [ISS]
- lysosomal membrane [IDA, ISS, TAS]
- membrane [IDA]
- neuron projection [ISS]
- phagocytic vesicle [ISS]
- plasma membrane [IDA, TAS]
- platelet alpha granule [IDA]
- pseudopodium [IDA]
- secretory granule [IDA]
- secretory granule membrane [IDA]
- trans-Golgi network [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
Loss of functional RAB18 causes the autosomal recessive condition Warburg Micro syndrome. To better understand this disease, we used proximity biotinylation to generate an inventory of potential RAB18 effectors. A restricted set of 28 RAB18-interactions were dependent on the binary RAB3GAP1-RAB3GAP2 RAB18-guanine nucleotide exchange factor (GEF) complex. 12 of these 28 interactions are supported by prior reports and we have ... [more]
J Biol Chem Sep. 27, 2023; ();105295 [Pubmed: 37774976]
Throughput
- High Throughput
Additional Notes
- BioID
- HeLa cells
- Presence in 2 or more replicate experiments
Curated By
- BioGRID