TNFRSF1A
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IMP]
- cytokine-mediated signaling pathway [IMP]
- defense response [IMP]
- defense response to bacterium [IMP]
- inflammatory response [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-6 production [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- programmed cell death [IPI]
- prostaglandin metabolic process [TAS]
- protein heterooligomerization [ISO]
- regulation of apoptotic process [ISO]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld-/- and Spata2-/- mice are viable, double mutants exhibit highly penetrant perinatal lethality, indicating independent functions of SPATA2 and CYLD. Cyld-/-Spata2-/- ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
- TNFR1 complex IP'd by pulling down TNF
Curated By
- BioGRID