BAIT
CLEC16A
Gop-1, KIAA0350
C-type lectin domain family 16, member A
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PYCR1
ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
pyrroline-5-carboxylate reductase 1
GO Process (7)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cellular amino acid biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- cellular response to oxidative stress [IMP]
- negative regulation of hydrogen peroxide-induced cell death [IMP]
- proline biosynthetic process [IDA]
- regulation of mitochondrial membrane potential [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.
CLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and reportedly localizes to late endosomes. GWAS studies have associated CLEC16A SNPs to various auto-immune and neurological disorders, including multiple sclerosis and Parkinson disease. Studies in mouse models imply a role for CLEC16A in neurodegeneration. We identified bi-allelic CLEC16A truncating variants in ... [more]
Hum Genet Mar. 01, 2023; 142(3);379-397 [Pubmed: 36538041]
Throughput
- Low Throughput
Curated By
- BioGRID