BAIT
BAD
BBC2, BCL2L8
BCL2-associated agonist of cell death
GO Process (33)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- ADP metabolic process [ISS]
- ATP metabolic process [ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- apoptotic process [IDA, TAS]
- apoptotic signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to nicotine [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- extrinsic apoptotic signaling pathway [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose homeostasis [ISS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [IMP, TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- pore complex assembly [IDA]
- positive regulation of apoptotic process [IDA, IMP, TAS]
- positive regulation of autophagy [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of glucokinase activity [ISS]
- positive regulation of insulin secretion [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [TAS]
- positive regulation of mitochondrial membrane potential [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of proteolysis [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- positive regulation of type B pancreatic cell development [ISS]
- regulation of mitochondrial membrane permeability [IMP]
- type B pancreatic cell proliferation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BOK
BCL2L9, BOKL
BCL2-related ovarian killer
GO Process (7)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic process [IDA]
- cell proliferation [IEP]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- positive regulation of execution phase of apoptosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
Although single-gene perturbation screens have revealed a number of new targets, vulnerabilities specific to frequently altered drivers have not been uncovered. An important question is whether the compensatory relationship between functionally redundant genes masks potential therapeutic targets in single-gene perturbation studies. To identify digenic dependencies, we developed a CRISPR paralog targeting library to investigate the viability effects of disrupting 3,284 ... [more]
Nat Genet Dec. 01, 2021; 53(12);1664-1672 [Pubmed: 34857952]
Quantitative Score
- 0.040076819 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CRISPR GI screen
- Cell Line: IPC298_SKIN score (0.0400768190388962)
- Cell Line: MEL202_UVEA score (0.0047028846477392)
- Experimental Setup: Timecourse-Synthetic Lethality
- GIST: A-phenotypic negative genetic interaction
- Library: Digenic Paralog CRISPR library
- Significance Threshold: GEMINI FDR < 0.05
Curated By
- BioGRID