BAIT
NRP1
BDCA4, CD304, NP1, NRP, VEGF165R, RP11-342D11.1
neuropilin 1
GO Process (43)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- angiogenesis [IMP, ISS]
- angiogenesis involved in coronary vascular morphogenesis [ISS]
- artery morphogenesis [ISS]
- axon extension involved in axon guidance [ISS]
- axon guidance [NAS, TAS]
- axonogenesis involved in innervation [ISS]
- cell migration involved in sprouting angiogenesis [ISS]
- cell-cell signaling [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [ISS]
- commissural neuron axon guidance [ISS]
- endothelial cell chemotaxis [IMP]
- endothelial tip cell fate specification [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- nerve development [ISS]
- neural crest cell migration involved in autonomic nervous system development [ISS]
- neuron migration [ISS]
- organ morphogenesis [TAS]
- patterning of blood vessels [ISS]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of cytokine activity [TAS]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of endothelial cell proliferation [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of smooth muscle cell migration [TAS]
- protein localization to early endosome [ISS]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of vesicle-mediated transport [TAS]
- retina vasculature morphogenesis in camera-type eye [ISS]
- retinal ganglion cell axon guidance [ISS]
- semaphorin-plexin signaling pathway [NAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- sympathetic ganglion development [ISS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
- vascular endothelial growth factor receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FAS
AI196731, APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr
Fas (TNF receptor superfamily member 6)
GO Process (39)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- B cell mediated immunity [IMP]
- T cell homeostasis [IMP]
- activation-induced cell death of T cells [IDA, IMP]
- apoptotic process [IMP, ISO]
- apoptotic signaling pathway [IDA, ISO]
- cellular response to hyperoxia [ISO]
- cellular response to lithium ion [IMP]
- dendrite regeneration [ISO]
- extrinsic apoptotic signaling pathway [IDA, IMP, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA, IGI, IMP]
- gene expression [IMP]
- hepatocyte apoptotic process [IGI]
- immunoglobulin production [IMP]
- inflammatory cell apoptotic process [IDA, IMP]
- motor neuron apoptotic process [IMP]
- necroptotic signaling pathway [IGI, ISO]
- negative regulation of B cell activation [IMP]
- negative regulation of apoptotic process [IDA]
- negative thymic T cell selection [IMP]
- neuron apoptotic process [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of protein homooligomerization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IC]
- protein homooligomerization [IDA]
- regulation of apoptotic process [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- regulation of lymphocyte differentiation [IMP]
- regulation of myeloid cell differentiation [IMP]
- renal system process [IMP]
- response to glucocorticoid [IMP]
- response to toxic substance [IMP]
- spleen development [IMP]
- transformed cell apoptotic process [IDA]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- CD95 death-inducing signaling complex [IDA, ISO]
- apical dendrite [ISO]
- apical plasma membrane [ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- death-inducing signaling complex [ISO]
- external side of plasma membrane [IDA]
- extracellular region [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- membrane raft [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
- secretory granule [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.
Liver fibrosis is a complex fibrotic process that develops early in the course of cirrhosis and is caused by chronic liver damage. The activation of hepatic stellate cells is primarily responsible for the fibrosis process. Studies show that NRP1 influences HSC motility and migration. However, whether NRP1 regulates HSC activation remains unknown. C57BL/6 male mice (6-8 weeks old) were intraperitoneally ... [more]
Cell Death Dis Jan. 19, 2023; 14(1);40 [Pubmed: 36653359]
Throughput
- High Throughput
Additional Notes
- Source of NRP1 not clear
Curated By
- BioGRID