BAIT
DCAF6
1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326, RP4-745I14.1
DDB1 and CUL4 associated factor 6
GO Process (2)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EHMT2
BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, DAAP-66K18.3
euchromatic histone-lysine N-methyltransferase 2
GO Process (6)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.
Inflammation and apoptosis are two important pathological causes of intervertebral disc degeneration (IDD). The crosstalk between these two biological processes during IDD pathogenesis remains elusive. Herein, we discovered that chronic inflammation induced apoptosis through a cullin-RING E3 ligase (CRL)-dependent mechanism. Two cullin proteins, CUL4A and 4B, recruited DNA damage-binding protein 1 (DDB1), RING-box protein 1 (RBX1) and DDB1- and CUL4-associated ... [more]
J Mol Med (Berl) Feb. 01, 2023; 101(1-2);171-181 [Pubmed: 36688959]
Throughput
- High Throughput
Curated By
- BioGRID