BAIT
RGS12
RP11-529E10.1
regulator of G-protein signaling 12
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HERC2
D15F37S1, MRT38, SHEP1, jdf2, p528
HECT and RLD domain containing E3 ubiquitin protein ligase 2
GO Process (6)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.
Synovial fibroblasts are the active and aggressive drivers in the progression of arthritis, but the cellular and molecular mechanisms remain unknown. Here, our results showed that regulator of G protein signaling 12 (RGS12) maintained ciliogenesis in synovial fibroblasts, which is critical for the development of inflammatory arthritis. Deletion of RGS12 led to a significant decrease in ciliogenesis, adhesion, migration, and ... [more]
Mol Ther Nucleic Acids Mar. 14, 2023; 31();197-210 [Pubmed: 36700049]
Throughput
- Low Throughput
Curated By
- BioGRID