BAIT

KIAA0101

PAF15, p15PAF, paf
KIAA0101
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis
PREY

KPNA4

ipoa3, qip1, srp3
karyopherin alpha 4 (importin alpha 3)
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5.

Miyashita R, Nishiyama A, Qin W, Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K, Nakanishi M

UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation of PAF15 (PAF15Ub2), which regulates the localization and activation of DNMT1 at DNA methylation sites during DNA replication. Although the initiation of UHRF1-mediated PAF15 ubiquitin signaling has been relatively well characterized, the mechanisms underlying its termination and how they are coordinated ... [more]

Elife Feb. 03, 2023; 12(); [Pubmed: 36734974]

Throughput

  • Low Throughput

Curated By

  • BioGRID