An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

Fan X, Yang H, Zhao C, Hu L, Wang D, Wang R, Fang Z, Chen X

A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local anesthetics in cancer stem cells. This study aimed to determine the possible role of local anesthetics in glioblastoma stem cell (GSC) self-renewal and the underlying ... [more]

Stem Cell Res Ther Feb. 04, 2021; 12(1);107 [Pubmed: 33541421]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

ZDHHC15

Gene Ontology Biological Process

Gene Ontology Molecular Function

palmitoyltransferase activity [IDA]

Gene Ontology Cellular Component

KIAA1217