An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-?B-dependent inflammation response.

Lou LQ, Zhou WQ, Song X, Chen Z

Nuclear factor-?B (NF-?B)-mediated inflammation is a major cause of acute respiratory distress syndrome (ARDS). However, the regulatory mechanisms by which NF-?B transactivates proinflammatory cytokines remain unclear in the pathogenesis of ARDS. Herein, we report that the activating protein 1 (AP1) transcription factor recruits a histone acetyltransferase p300 and a transcriptional regulator C-terminal binding protein 1 (CtBP1) to assemble the CtBP1-p300-AP1 ... [more]

J Mol Med (Berl) Mar. 01, 2023; 101(3);223-235 [Pubmed: 36629882]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

ATXN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [IPI]poly(G) binding [IDA]poly(U) RNA binding [IDA]protein C-terminus binding [IPI]protein binding [IPI]protein self-association [IDA]

Gene Ontology Cellular Component

POFUT2