BAIT
JUN
AP-1, Junc, c-jun, RP23-135A21.5
jun proto-oncogene
GO Process (43)
GO Function (21)
GO Component (7)
Gene Ontology Biological Process
- SMAD protein import into nucleus [ISO]
- SMAD protein signal transduction [ISO]
- angiogenesis [IMP, ISO]
- axon regeneration [IMP]
- cellular process [IMP]
- cellular response to calcium ion [IDA]
- cellular response to potassium ion starvation [ISO]
- leading edge cell differentiation [IMP]
- learning [ISO]
- liver development [IMP]
- membrane depolarization [ISO]
- microglial cell activation [IMP]
- monocyte differentiation [IMP]
- negative regulation by host of viral transcription [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IGI]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of protein autophosphorylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- outflow tract morphogenesis [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IDA, IGI]
- positive regulation of monocyte differentiation [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell cycle [IMP]
- regulation of transcription, DNA-templated [IMP]
- release of cytochrome c from mitochondria [ISO]
- response to drug [IDA]
- response to muscle stretch [IDA]
- response to radiation [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- HMG box domain binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- Rho GTPase activator activity [ISO]
- cAMP response element binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA]
- HMG box domain binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- Rho GTPase activator activity [ISO]
- cAMP response element binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
CTBP1
BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115, D5H4S115E
C-terminal binding protein 1
GO Process (10)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- Golgi organization [ISO]
- chromatin organization involved in regulation of transcription [ISO]
- negative regulation of histone H4 acetylation [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of histone deacetylation [ISO]
- regulation of cell cycle [ISO]
- transcription from RNA polymerase II promoter [ISO]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-?B-dependent inflammation response.
Nuclear factor-?B (NF-?B)-mediated inflammation is a major cause of acute respiratory distress syndrome (ARDS). However, the regulatory mechanisms by which NF-?B transactivates proinflammatory cytokines remain unclear in the pathogenesis of ARDS. Herein, we report that the activating protein 1 (AP1) transcription factor recruits a histone acetyltransferase p300 and a transcriptional regulator C-terminal binding protein 1 (CtBP1) to assemble the CtBP1-p300-AP1 ... [more]
J Mol Med (Berl) Mar. 01, 2023; 101(3);223-235 [Pubmed: 36629882]
Throughput
- Low Throughput
Curated By
- BioGRID