PREY
HSP90AB1
D6S182, HSP84, HSP90B, HSPC2, HSPCB, RP1-302G2.1
heat shock protein 90kDa alpha (cytosolic), class B member 1
GO Process (9)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- regulation of interferon-gamma-mediated signaling pathway [IMP]
- regulation of type I interferon-mediated signaling pathway [IMP]
- response to unfolded protein [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.
Cells use ubiquitin to mark proteins for proteasomal degradation. Although the proteasome also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is unclear. Here, we found that midnolin promoted the destruction of many nuclear proteins, including transcription factors encoded by the immediate-early genes. Diverse stimuli induced midnolin, and its overexpression was sufficient to cause the degradation of its ... [more]
Science Aug. 25, 2023; 381(6660);eadh5021 [Pubmed: 37616343]
Throughput
- High Throughput
Additional Notes
- HA-tagged Midnolin expressed in HEK-293T cells treated with DMSO.
- HA-tagged Midnolin expressed in HEK-293T cells treated with the proteasome inhibitor MG132.
Curated By
- BioGRID