BAIT
SPOP
BTBD32, TEF2
speckle-type POZ protein
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HRAS
C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
Harvey rat sarcoma viral oncogene homolog
GO Process (39)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [IDA, TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell cycle arrest [IDA, IMP]
- cell surface receptor signaling pathway [TAS]
- cellular senescence [IDA]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- mitotic cell cycle checkpoint [IDA]
- negative regulation of Rho GTPase activity [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of gene expression [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of actin cytoskeleton reorganization [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of miRNA metabolic process [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of ruffle assembly [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of wound healing [IDA]
- signal transduction [NAS]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.
Aberrantly elevated O-GlcNAcylation level is commonly observed in human cancer patients, and has been proposed as a potential therapeutic target. Speckle-type POZ protein (SPOP), an important substrate adaptor of cullin3-RING ubiquitin ligase, plays a key role in the initiation and development of various cancers. However, the regulatory mechanisms governing SPOP and its function during hepatocellular carcinoma (HCC) progression remain unclear. ... [more]
Oncogene Mar. 01, 2023; 42(10);725-736 [Pubmed: 36604567]
Throughput
- Low Throughput
Curated By
- BioGRID