BAIT
SPOP
BTBD32, TEF2
speckle-type POZ protein
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB3A
RAB3A, member RAS oncogene family
GO Process (16)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Rab protein signal transduction [IBA]
- constitutive secretory pathway [TAS]
- glutamate secretion [TAS]
- intracellular protein transport [IBA]
- neurotransmitter secretion [TAS]
- positive regulation of exocytosis [TAS]
- positive regulation of regulated secretory pathway [IMP]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of short-term neuronal synaptic plasticity [ISS]
- regulation of synaptic vesicle fusion to presynaptic membrane [ISS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [ISS]
- synaptic vesicle recycling [ISS]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- clathrin-sculpted acetylcholine transport vesicle membrane [TAS]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- clathrin-sculpted glutamate transport vesicle membrane [TAS]
- clathrin-sculpted monoamine transport vesicle membrane [TAS]
- endosome [IBA]
- plasma membrane [TAS]
- secretory granule membrane [IBA]
- synaptic vesicle [ISS]
- terminal bouton [ISS]
- vesicle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.
Aberrantly elevated O-GlcNAcylation level is commonly observed in human cancer patients, and has been proposed as a potential therapeutic target. Speckle-type POZ protein (SPOP), an important substrate adaptor of cullin3-RING ubiquitin ligase, plays a key role in the initiation and development of various cancers. However, the regulatory mechanisms governing SPOP and its function during hepatocellular carcinoma (HCC) progression remain unclear. ... [more]
Oncogene Mar. 01, 2023; 42(10);725-736 [Pubmed: 36604567]
Throughput
- Low Throughput
Curated By
- BioGRID