BAIT
SPOP
BTBD32, TEF2
speckle-type POZ protein
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MARK2
EMK-1, EMK1, PAR-1, Par-1b, Par1b
MAP/microtubule affinity-regulating kinase 2
GO Process (13)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- activation of protein kinase activity [TAS]
- establishment of cell polarity [IDA, TAS]
- establishment or maintenance of epithelial cell apical/basal polarity [IDA]
- intracellular signal transduction [IDA]
- mitochondrion degradation [NAS]
- mitochondrion localization [NAS]
- neuron migration [ISS]
- peptidyl-threonine phosphorylation [TAS]
- positive regulation of neuron projection development [IDA]
- protein autophosphorylation [ISS]
- protein phosphorylation [IDA, NAS]
- regulation of axonogenesis [IMP]
- regulation of cytoskeleton organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.
Aberrantly elevated O-GlcNAcylation level is commonly observed in human cancer patients, and has been proposed as a potential therapeutic target. Speckle-type POZ protein (SPOP), an important substrate adaptor of cullin3-RING ubiquitin ligase, plays a key role in the initiation and development of various cancers. However, the regulatory mechanisms governing SPOP and its function during hepatocellular carcinoma (HCC) progression remain unclear. ... [more]
Oncogene Mar. 01, 2023; 42(10);725-736 [Pubmed: 36604567]
Throughput
- Low Throughput
Curated By
- BioGRID