BAIT
RNF207
C1orf188
ring finger protein 207
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
HSPA5
BIP, GRP78
heat shock protein 5
GO Process (16)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- ER overload response [ISO]
- activation of signaling protein activity involved in unfolded protein response [ISO]
- cellular response to antibiotic [IEP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [ISO]
- cerebellar Purkinje cell layer development [ISO]
- cerebellum structural organization [ISO]
- maintenance of protein localization in endoplasmic reticulum [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of protein ubiquitination [ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
- response to endoplasmic reticulum stress [IDA]
- substantia nigra development [ISO]
- toxin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [ISO]
- endoplasmic reticulum [IDA, ISO, TAS]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [ISO]
- endoplasmic reticulum membrane [ISO]
- endoplasmic reticulum-Golgi intermediate compartment [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [IDA, ISO]
- midbody [ISO]
- mitochondrion [IDA]
- myelin sheath [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- smooth endoplasmic reticulum [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
The heart undergoes pathological remodelling, featured by the hypertrophic growth of cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as haemodynamic overload. Ring Finger Protein 207 (RNF207) is an E3 ubiquitin ligase that is predominantly expressed in the heart, but its function remains elusive. In this study, we aimed to explore the role of RNF207 in the development of ... [more]
Cardiovasc Res Mar. 17, 2023; 119(1);183-194 [Pubmed: 35352799]
Throughput
- High Throughput
Curated By
- BioGRID