BAIT
RNF207
C1orf188
ring finger protein 207
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
NPM1
B23NP
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
GO Process (38)
GO Function (17)
GO Component (16)
Gene Ontology Biological Process
- DNA repair [ISO, ISS]
- cell aging [ISO, ISS]
- cell growth [ISO]
- cell volume homeostasis [ISO]
- centrosome cycle [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of centrosome duplication [ISO]
- negative regulation of mRNA splicing, via spliceosome [ISO]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [ISO, ISS]
- nucleocytoplasmic transport [ISO]
- nucleosome assembly [ISO]
- positive regulation of DNA metabolic process [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of catalytic activity [IDA]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular biosynthetic process [ISO]
- positive regulation of centrosome duplication [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of translation [ISO, ISS]
- protein destabilization [ISO]
- protein homooligomerization [IDA]
- protein localization [ISO]
- protein oligomerization [ISO]
- rRNA export from nucleus [ISO]
- regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- regulation of cell cycle [ISO]
- regulation of centriole replication [ISO, ISS]
- regulation of centrosome duplication [ISO]
- regulation of eIF2 alpha phosphorylation by dsRNA [ISO, ISS]
- regulation of endodeoxyribonuclease activity [ISO, ISS]
- regulation of endoribonuclease activity [ISO, ISS]
- regulation of neuron apoptotic process [IMP]
- ribosomal large subunit biogenesis [ISO]
- ribosomal large subunit export from nucleus [ISO]
- ribosomal small subunit biogenesis [ISO]
- ribosomal small subunit export from nucleus [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- NF-kappaB binding [ISO, ISS]
- RNA binding [ISO]
- Tat protein binding [ISO]
- enzyme binding [IDA, IPI]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [IPI]
- poly(A) RNA binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO, ISS]
- rRNA binding [ISO]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO, ISS]
- DNA binding [IDA]
- NF-kappaB binding [ISO, ISS]
- RNA binding [ISO]
- Tat protein binding [ISO]
- enzyme binding [IDA, IPI]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [IPI]
- poly(A) RNA binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO, ISS]
- rRNA binding [ISO]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO, ISS]
Gene Ontology Cellular Component
- cell [ISO]
- centrosome [ISO, ISS]
- cytoplasm [ISO, ISS]
- cytosol [ISO]
- focal adhesion [ISO]
- granular component [ISO]
- intracellular [ISO]
- large ribosomal subunit [ISO]
- membrane [ISO]
- nuclear speck [ISO]
- nucleolus [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [ISO, ISS]
- ribonucleoprotein complex [ISO]
- small ribosomal subunit [ISO]
- spindle pole centrosome [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
The heart undergoes pathological remodelling, featured by the hypertrophic growth of cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as haemodynamic overload. Ring Finger Protein 207 (RNF207) is an E3 ubiquitin ligase that is predominantly expressed in the heart, but its function remains elusive. In this study, we aimed to explore the role of RNF207 in the development of ... [more]
Cardiovasc Res Mar. 17, 2023; 119(1);183-194 [Pubmed: 35352799]
Throughput
- High Throughput
Curated By
- BioGRID