BAIT
RNF207
C1orf188
ring finger protein 207
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
CLU
APOJ, CLI, DAG, RATTRPM2B, SGP-2, SGP2, SP-40, SP40, TRPM-2, TRPM2B, Trpm2, Trpmb
clusterin
GO Process (40)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- aging [IEP]
- cell morphogenesis [ISO, ISS]
- cellular response to growth factor stimulus [IEP]
- central nervous system myelin maintenance [ISO, ISS]
- chaperone-mediated protein complex assembly [ISO, ISS]
- chaperone-mediated protein folding [ISO, ISS]
- endocrine pancreas development [IMP]
- estrous cycle [IEP]
- intrinsic apoptotic signaling pathway [ISO, ISS]
- microglial cell activation [ISO, ISS]
- microglial cell proliferation [ISO, ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of beta-amyloid formation [ISO, ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO, ISS]
- negative regulation of protein homooligomerization [ISO, ISS]
- neuron projection morphogenesis [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of beta-amyloid formation [ISS]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [ISO, ISS]
- positive regulation of neurofibrillary tangle assembly [ISO, ISS]
- positive regulation of neuron death [ISO, ISS]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of tau-protein kinase activity [ISO, ISS]
- positive regulation of tumor necrosis factor production [ISO, ISS]
- protein import [ISO, ISS]
- protein stabilization [ISO, ISS]
- regulation of beta-amyloid clearance [ISO, ISS]
- regulation of neuron death [ISO, ISS]
- regulation of neuronal signal transduction [ISO, ISS]
- response to light stimulus [IEP]
- response to misfolded protein [ISO, ISS]
- response to oxidative stress [IEP]
- response to potassium ion [IEP]
- response to virus [ISO]
- response to wounding [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- aggresome [IDA]
- apical dendrite [ISO, ISS]
- blood microparticle [ISO]
- cytoplasm [IDA, ISO, ISS]
- extracellular matrix [ISO, ISS]
- extracellular space [IDA, ISO, ISS]
- extracellular vesicular exosome [ISO]
- growth cone [IDA]
- mitochondrion [ISO]
- neurofibrillary tangle [ISO, ISS]
- neuron projection [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA, ISO]
- spherical high-density lipoprotein particle [ISO, ISS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
The heart undergoes pathological remodelling, featured by the hypertrophic growth of cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as haemodynamic overload. Ring Finger Protein 207 (RNF207) is an E3 ubiquitin ligase that is predominantly expressed in the heart, but its function remains elusive. In this study, we aimed to explore the role of RNF207 in the development of ... [more]
Cardiovasc Res Mar. 17, 2023; 119(1);183-194 [Pubmed: 35352799]
Throughput
- High Throughput
Curated By
- BioGRID