BAIT
RNF207
C1orf188
ring finger protein 207
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ITGB1
integrin, beta 1
GO Process (58)
GO Function (18)
GO Component (32)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- axon extension [ISO]
- calcium-independent cell-matrix adhesion [ISO]
- cardiac muscle cell differentiation [ISO]
- cardiac muscle tissue development [ISO]
- cell adhesion [IDA]
- cell fate specification [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cell-cell adhesion mediated by integrin [ISO]
- cell-matrix adhesion [ISO]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [IDA]
- cellular response to ionizing radiation [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to vitamin D [IEP]
- dendrite morphogenesis [ISO]
- formation of radial glial scaffolds [ISO]
- germ cell migration [ISO]
- heterotypic cell-cell adhesion [ISO]
- in utero embryonic development [ISO]
- integrin-mediated signaling pathway [IDA, ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte tethering or rolling [ISO]
- maternal process involved in female pregnancy [IEP]
- mesodermal cell differentiation [ISO]
- negative regulation of Rho protein signal transduction [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of cell projection organization [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- neuron projection development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISO, ISS]
- positive regulation of neuron differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- protein transport within lipid bilayer [IMP]
- regulation of G-protein coupled receptor protein signaling pathway [IMP]
- regulation of cell cycle [ISO]
- regulation of collagen catabolic process [ISO, ISS]
- response to activity [IEP]
- response to drug [IEP]
- response to gonadotropin [IEP]
- response to nutrient levels [IEP]
- response to transforming growth factor beta [IEP]
- sarcomere organization [ISO]
- stress fiber assembly [ISO]
- tight junction assembly [IMP]
- tissue homeostasis [IMP]
- transforming growth factor beta receptor signaling pathway [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- actin binding [IDA, ISO]
- alpha-actinin binding [IDA]
- cell adhesion molecule binding [ISO]
- collagen binding [IDA]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [IDA]
- glycoprotein binding [IPI]
- integrin binding [IMP, IPI, ISO]
- kinase binding [IPI]
- laminin binding [IDA, IMP, ISO]
- peptide binding [IDA]
- protease binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IDA]
- protein heterodimerization activity [IC, IMP, IPI, ISO]
- protein kinase binding [IPI]
- receptor binding [IPI]
- actin binding [IDA, ISO]
- alpha-actinin binding [IDA]
- cell adhesion molecule binding [ISO]
- collagen binding [IDA]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [IDA]
- glycoprotein binding [IPI]
- integrin binding [IMP, IPI, ISO]
- kinase binding [IPI]
- laminin binding [IDA, IMP, ISO]
- peptide binding [IDA]
- protease binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IDA]
- protein heterodimerization activity [IC, IMP, IPI, ISO]
- protein kinase binding [IPI]
- receptor binding [IPI]
Gene Ontology Cellular Component
- acrosomal vesicle [IDA]
- adherens junction [IDA]
- basement membrane [IDA]
- cell surface [IDA, ISO]
- cell-cell junction [IDA]
- cytoplasm [ISO]
- dendritic spine [ISO]
- external side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [IDA, ISO]
- hemidesmosome [IDA]
- integrin alpha1-beta1 complex [ISO]
- integrin alpha10-beta1 complex [ISO]
- integrin alpha11-beta1 complex [ISO]
- integrin alpha2-beta1 complex [ISO]
- integrin alpha3-beta1 complex [IDA, ISO]
- integrin alpha7-beta1 complex [ISO]
- integrin alpha9-beta1 complex [IDA]
- integrin complex [IC, IDA]
- intercalated disc [ISO]
- invadopodium membrane [ISO, ISS]
- membrane [IDA, ISO]
- membrane raft [IDA, ISO]
- myelin sheath abaxonal region [ISO]
- neuromuscular junction [ISO]
- plasma membrane [ISO, TAS]
- receptor complex [ISO]
- ruffle membrane [ISO]
- sarcolemma [ISO]
- synapse [ISO]
- synaptic membrane [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
The heart undergoes pathological remodelling, featured by the hypertrophic growth of cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as haemodynamic overload. Ring Finger Protein 207 (RNF207) is an E3 ubiquitin ligase that is predominantly expressed in the heart, but its function remains elusive. In this study, we aimed to explore the role of RNF207 in the development of ... [more]
Cardiovasc Res Mar. 17, 2023; 119(1);183-194 [Pubmed: 35352799]
Throughput
- High Throughput
Curated By
- BioGRID