BAIT
RNF207
C1orf188
ring finger protein 207
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
NEDD4
Nedd4a
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
GO Process (35)
GO Function (12)
GO Component (13)
Gene Ontology Biological Process
- T cell activation [ISO]
- adaptive immune response [ISO]
- blood vessel morphogenesis [ISO]
- cellular response to UV [ISO]
- development involved in symbiotic interaction [ISO]
- endocardial cushion development [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- immune response [IEP]
- lysosomal transport [ISO]
- negative regulation of sodium ion transport [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- neuromuscular junction development [ISO]
- neuron projection development [ISO]
- outflow tract morphogenesis [ISO]
- positive regulation of nucleocytoplasmic transport [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein catabolic process [ISO]
- progesterone receptor signaling pathway [ISO]
- protein K63-linked ubiquitination [IDA]
- protein monoubiquitination [ISO]
- protein targeting to lysosome [ISO]
- protein ubiquitination [ISO, ISS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, ISO]
- receptor catabolic process [ISO]
- receptor internalization [ISO]
- regulation of dendrite morphogenesis [IDA, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- regulation of synapse organization [ISO]
- response to denervation involved in regulation of muscle adaptation [IEP]
- transmission of virus [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
Gene Ontology Molecular Function- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
The heart undergoes pathological remodelling, featured by the hypertrophic growth of cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as haemodynamic overload. Ring Finger Protein 207 (RNF207) is an E3 ubiquitin ligase that is predominantly expressed in the heart, but its function remains elusive. In this study, we aimed to explore the role of RNF207 in the development of ... [more]
Cardiovasc Res Mar. 17, 2023; 119(1);183-194 [Pubmed: 35352799]
Throughput
- High Throughput
Curated By
- BioGRID