Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

ZNF212 promotes genomic integrity through direct interaction with TRAIP.

Chung HJ, Lee JR, Kim TM, Kim S, Park K, Kim MJ, Jung E, Kim S, Lee EA, Ra JS, Hwang S, Lee JY, Schaerer OD, Kim Y, Myung K, Kim H

TRAIP is a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair. However, the exact functions of TRAIP in these processes in mammalian cells are not fully understood. Here we identify the zinc finger protein 212, ZNF212, as a novel binding partner for TRAIP and find that ZNF212 colocalizes with sites ... [more]

Nucleic Acids Res Jan. 25, 2023; 51(2);631-649 [Pubmed: 36594163]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TRAIP

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]receptor signaling protein activity [IPI]ubiquitin protein ligase activity [IDA]ubiquitin-protein transferase activity [IDA]

VIM

Gene Ontology Biological Process

Gene Ontology Molecular Function

double-stranded RNA binding [IDA]glycoprotein binding [IPI]identical protein binding [IPI]protein C-terminus binding [IPI]protein binding [IPI]scaffold protein binding [IPI]structural constituent of cytoskeleton [IDA]

Gene Ontology Cellular Component

Two-hybrid

Publication

ZNF212 promotes genomic integrity through direct interaction with TRAIP.

Throughput

Curated By

protein binding [IPI]
receptor signaling protein activity [IPI]
ubiquitin protein ligase activity [IDA]
ubiquitin-protein transferase activity [IDA]

double-stranded RNA binding [IDA]
glycoprotein binding [IPI]
identical protein binding [IPI]
protein C-terminus binding [IPI]
protein binding [IPI]
scaffold protein binding [IPI]
structural constituent of cytoskeleton [IDA]