BAIT
ESYT1
FAM62A, MBC2
extended synaptotagmin-like protein 1
GO Process (0)
GO Function (2)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A10
DIC
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
GO Process (11)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- dicarboxylic acid transport [TAS]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- ion transport [TAS]
- small molecule metabolic process [TAS]
- sulfide oxidation, using sulfide:quinone oxidoreductase [TAS]
- sulfur amino acid catabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.
Mitochondria interact with the ER at structurally and functionally specialized membrane contact sites known as mitochondria-ER contact sites (MERCs). Combining proximity labelling (BioID), co-immunoprecipitation, confocal microscopy and subcellular fractionation, we found that the ER resident SMP-domain protein ESYT1 was enriched at MERCs, where it forms a complex with the outer mitochondrial membrane protein SYNJ2BP. BioID analyses using ER-targeted, outer mitochondrial ... [more]
Life Sci Alliance Jan. 01, 2024; 7(1); [Pubmed: 37931956]
Throughput
- Low Throughput
Curated By
- BioGRID