BAIT

ESYT1

Fam62a, Mbc2, vp115
extended synaptotagmin-like protein 1
GO Process (0)
GO Function (1)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

SYNJ2BP

AA409442, ARIP2, ARIP2a, ActRIP4, D12Wsu118e, OMP25
synaptojanin 2 binding protein
Mus musculus

Co-purification

An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.

Publication

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.

Janer A, Morris JL, Krols M, Antonicka H, Aaltonen MJ, Lin ZY, Anand H, Gingras AC, Prudent J, Shoubridge EA

Mitochondria interact with the ER at structurally and functionally specialized membrane contact sites known as mitochondria-ER contact sites (MERCs). Combining proximity labelling (BioID), co-immunoprecipitation, confocal microscopy and subcellular fractionation, we found that the ER resident SMP-domain protein ESYT1 was enriched at MERCs, where it forms a complex with the outer mitochondrial membrane protein SYNJ2BP. BioID analyses using ER-targeted, outer mitochondrial ... [more]

Life Sci Alliance Jan. 01, 2024; 7(1); [Pubmed: 37931956]

Throughput

  • Low Throughput

Curated By

  • BioGRID