CHD1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- chromatin organization involved in regulation of transcription [IGI, IMP]
- histone H2B conserved C-terminal lysine ubiquitination [IMP]
- negative regulation of DNA-dependent DNA replication [IGI]
- negative regulation of histone H3-K14 acetylation [IMP]
- negative regulation of histone H3-K9 acetylation [IMP]
- negative regulation of histone exchange [IMP]
- nucleosome mobilization [IDA]
- nucleosome positioning [IDA, IGI]
- regulation of chromatin organization [IMP]
- regulation of transcriptional start site selection at RNA polymerase II promoter [IGI]
- termination of RNA polymerase I transcription [IGI]
- termination of RNA polymerase II transcription [IGI, IMP]
- transcription elongation from RNA polymerase II promoter [IGI, IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RSC8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- RSC complex [IDA]
- nucleus [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The social and structural architecture of the yeast protein interactome.
Cellular functions are mediated by protein-protein interactions, and mapping the interactome provides fundamental insights into biological systems. Affinity purification coupled to mass spectrometry is an ideal tool for such mapping, but it has been difficult to identify low copy number complexes, membrane complexes and complexes that are disrupted by protein tagging. As a result, our current knowledge of the interactome ... [more]
Quantitative Score
- 4.0 [Score_FDR+correlation]
Throughput
- High Throughput
Additional Notes
- Protein interactions were identified using statistically significant enrichment of the proteins in the forward and reverse pull-downs, as well as making use of the profile similarities of interacting proteins in a correlation analysis. High confidence interactions have a total score >=2. This score is a sum of the FDR score of the forward pull-down + FDR score of the reverse pull-down + correlation score.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RSC8 CHD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -8.3685 | BioGRID | 214878 | |
| RSC8 CHD1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2599724 |
Curated By
- BioGRID