BAIT
SMC5
SMC5L1
structural maintenance of chromosomes 5
GO Process (6)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- cellular senescence [IMP]
- double-strand break repair via homologous recombination [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- telomere maintenance via recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DSP
DCWHKTA, DP, DPI, DPII
desmoplakin
GO Process (12)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- desmosome organization [ISS]
- epidermis development [TAS]
- intermediate filament organization [ISS]
- keratinocyte differentiation [IDA]
- peptide cross-linking [IDA]
- protein localization to adherens junction [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular compact myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.
The human SMC5/6 complex is a conserved guardian of genome stability and an emerging component of antiviral responses. These disparate functions likely require distinct mechanisms of SMC5/6 regulation. In yeast, Smc5/6 is regulated by its Nse5/6 subunits, but such regulatory subunits for human SMC5/6 are poorly defined. Here, we identify a novel SMC5/6 subunit called SIMC1 that contains SUMO interacting ... [more]
Elife Nov. 14, 2022; 11(); [Pubmed: 36373674]
Throughput
- Low Throughput
Curated By
- BioGRID