SED5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
POL1
Gene Ontology Biological Process
- DNA replication [IMP]
- DNA replication checkpoint [IBA]
- DNA replication initiation [IC]
- DNA replication, synthesis of RNA primer [IBA]
- DNA strand elongation involved in DNA replication [IBA]
- DNA synthesis involved in DNA repair [IMP]
- RNA-dependent DNA replication [IDA]
- double-strand break repair [IMP]
- gene conversion at mating-type locus, DNA repair synthesis [IBA]
- lagging strand elongation [IC]
- premeiotic DNA replication [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress.
Spatial sorting to discrete quality control sites in the cell is a process harnessing the toxicity of aberrant proteins. We show that the yeast t-snare phosphoprotein syntaxin5 (Sed5) acts as a key factor in mitigating proteotoxicity and the spatial deposition and clearance of IPOD (insoluble protein deposit) inclusions associates with the disaggregase Hsp104. Sed5 phosphorylation promotes dynamic movement of COPII-associated ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide accumulation (APO:0000149)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| POL1 SED5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1751 | BioGRID | 1948625 |
Curated By
- BioGRID