BAIT
GRM2
GLUR2, GPRC1B, MGLUR2, mGlu2
glutamate receptor, metabotropic 2
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EIF2AK2
EIF2AK1, PKR, PPP1R83, PRKR
eukaryotic translation initiation factor 2-alpha kinase 2
GO Process (22)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPKK activity [IMP]
- evasion or tolerance by virus of host immune response [TAS]
- modulation by virus of host morphology or physiology [TAS]
- modulation by virus of host process [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of translation [IDA, IMP]
- negative regulation of viral genome replication [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of NIK/NF-kappaB signaling [ISS]
- positive regulation of chemokine production [ISS]
- positive regulation of cytokine production [ISS]
- positive regulation of stress-activated MAPK cascade [ISS]
- protein autophosphorylation [IDA, IMP]
- protein phosphorylation [IDA]
- regulation of NLRP3 inflammasome complex assembly [ISS]
- regulation of hematopoietic progenitor cell differentiation [ISS]
- regulation of hematopoietic stem cell differentiation [ISS]
- regulation of hematopoietic stem cell proliferation [ISS]
- response to interferon-alpha [IDA]
- response to virus [IMP]
- viral life cycle [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.
Identification of bona fide functional receptors and elucidation of the mechanism of receptor-mediated virus entry are important to reveal targets for developing therapeutics against rabies virus (RABV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our previous studies suggest that metabotropic glutamate receptor subtype 2 (mGluR2) functions as an entry receptor for RABV in vitro, and is an important internalization ... [more]
J Virol Feb. 28, 2023; 97(2);e0161122 [Pubmed: 36779763]
Throughput
- High Throughput
Additional Notes
- Affinity capture-MS was carried out to identify high confidence protein interactors with the number of unique peptides being greater than or equal to 2 times over control in at least 2 replicates
Curated By
- BioGRID